c. 300 CE: CONSTANTINE!

Bust of the Emperor Constantine;
Palazzo dei Conservatori, Rome.

Constantine reversed the persecutions of his predecessor, Diocletion,and issued (with his co–sponsor Licinius) the Edict of Milan in 313 CE,which proclaimed religious toleration throughout the empire.

Born: Flavius Valerius Aurelius Constantinus

Commonly known in English as Constantine I and as Constantine the Great

Among Eastern Orthodox and Byzantine Catholics known as Saint Constantine