Prague, Bohemia-Tiberias, Eretz Israel
Known as the SheLaH Hakadosh for his major work Shnai Luchot Habrit (Two Tablets of the Covenant) which combines Halacha and Kabbalah as a way of life, Isaiah was perfect as Rabbi, kabbalist, and Jewish leader.
In 1621 after the death of his wife, he moved to Eretz Israel. In 1625 he was arrested with many other Rabbis and held for ransom by the Pasha.
As Ashkenazi Rabbi, Horowitz served as leader in Jerusalem. He served the community through his financial wealth and he believed that he was privileged to be able to observe the commandments tied to the land of Israel. He was buried in Tiberias, next to Maimonides.